期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1998
卷号：44
期号：6
页码：769-778
DOI：10.3177/jnsv.44.769
出版社：Center for Academic Publications Japan
摘要：The effects of dietary catechins and α-tocopherol on inflammatory bowel disease in rats were examined. Male 9-week-old rats were intracolonically administrated trinitrobenzene sulfonic acid (TNBS) and fed the experimental diets containing 0.05% catechin and 0.025% α-tocopherol for 1 week, then dissected. The extent of colitis-induced TNBS was assessed macroscopically. The supplementation of catechins and α-tocopherol significantly decreased colonic damage compared with the group fed the basal diet (the disease control). In particular, catechin feeding completely inhibited the development of colon adhesions. Colonic myeloperoxidase (MPO) activity, which is a marker of neutrophil infiltration into the colonic mucosa, was lower in the groups that had been given catechins and α-tocopherol. The levels of thiobarbituric acid reactive substances in colon was highest in the disease control group; however, the differences among the groups were not significant. Plasma alkaline phosphatase activity was maintained at normal levels in the rats supplemented with catechins and α-tocopherol. These results suggest that catechins and α-tocopherol have anti-inflammatory effects on TNBS-induced rat colitis.
