期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1977
卷号：23
期号：2
页码：95-100
DOI：10.3177/jnsv.23.95
出版社：Center for Academic Publications Japan
摘要：Dihydrofolate synthetase activity is widely distributed in various microorganisms and mushrooms. Animals and microorganisms i.e. , rat and chicken (in the liver), L. casei and P. cerevisiae , which require essentially pteroylglutamic acid as a nutrient for growth showed no detectable dihydrofolate synthetase activity. S. faecalis R, which can replace pteroylglutamic acid with pteroic acid as a nutrient for growth, had little dihydropteroate synthetase activity but showed normal dihydro-folate synthetase activity. This suggests that the nutritional requirements for folate compounds shown in vivo is in good agreement with the results obtained with dihydropteroate and dihydrofolate synthetase activities in vitro , and that the pathway through dihydropteroic acid as an intermediate is the main route in folate biosynthesis in nature.
