出版社：National Institute of Occupational Safety and Health
摘要：Two inclusion compounds, progesterone with β- and γ-cyclodextrin, were studied with X-ray powder diffractometry and thermal analysis. Disappearance of characteristic X-ray diffraction patterns of the two compounds as well as the appearance of a new diffraction pattern for each were found when formation of the inclusion compounds was completed. The X-ray diffraction patterns of β-cyclodextrin measured at various temperatures showed a structural change occurring between 60°C to 80°C, which coincided well with the DSC endothermic peak around 75°C. Results suggest that changes in the X-ray diffraction patterns of cyclodextrin during inclusion formation and during heating is due to the displacement of adsorbed water by progesterone in the cavity of cyclodextrin.
