出版社：National Institute of Occupational Safety and Health
摘要：Cystathionine γ-lyase activity in the sera of rats subjected to experimental hepatotoxicity after intraperitoneal administration of carbon tetrachloride (CCl4) was measured and compared with activities of aspartate aminotransferase (GOT) and alanine aminotransferase (GPT), which have been clinically used for detecting liver damage. In the experimental subjects, serum levels of cystathionine γ-lyase showed a similar behavior to GOT and GPT, increasing markedly with respect to the controls after administration of CCl4 and reaching a maximum at 24 hours. No such cystathionine γ-lyase activity was detected immunochemically in the control subjects. These data suggest that measurement of serum cystathionine γ-lyase activity could be used as a sensitive and specific marker of hepatic cytolysis.
