出版社：National Institute of Occupational Safety and Health
摘要：This report discribes the results of health examination of VCM workers in 1975 or 1976. All workers examined were healthy, and liver or spleen enlargement was not observed. By examining VCM workers, the measurement of blood catalase activity was ascertained to be seriously significant for VCM exposure, and it had been already found by us that the decrease of blood catalase activity in rats exposed with VCM occured corresponding to the concentration of VCM. The decrease of catalase activity in man was considered to be significant when the activity value was below 90%. When if the activity value was in normal range, the difference between the value and that obtained by following test should be taken into consideration. Effect of VCM on blood pressure has been discussed by some investigators. By our examination, rise of diastolic blood pressure was shown in some cases, but the rise should be explained by taking account of the results on catalase activity and blood platelets and so on. Although the activity of γ-GTP was an important factor for finding out the influence of VCM, it should be carefully treated by taking into account the other tests results when the increase was a little but not so large. Measurement of serum lipids such as triglycerides and free fatty acids etc. should be considered as a co-factor with the synthetic result of γ-GTP, blood platelets, reticulocytes, blood pressure and catalase activity. As the result of tracing examination of VCM workers for about one year, who have been exposed with VCM of 0.2 ppm or below for at least one year, it was assumed that serum proteins and surum bilirubin in Table 8 had been scarcely in-fluenced. Measurement of GOT, GPT and alkaline phosphtase (ALP) may be neces-sary for finding some disordered states of the liver, but not so serious for finding VCM influence in the first screening. As the screening test of VCM workers, blood catalase activity, γ-GTP, blood platelets, reticulocytes and blood pressure should be taken up, and the results of the tests should be considered synthetically and not independently. In the tests, since γ-GTP value increases by daily drinking and reduces fairly quickly by dis-continuation of drinking, the test must be carried out in an accustomed life-style, and the result should be carefully considered by making reference to the amount of drink if the worker drank habitually. The amount of VCM in the blood of workers was several ppb, and in 1976 it seemed to be less than that in 1975. In some workers, although the metabolic speed of VCM in the body has been considered to be rapid, VCM in the blood was detected after 48 hours apart from VCM works.
