出版社：National Institute of Occupational Safety and Health
摘要：Dimethyl sulfoxide (DMSO) and its metabolite, dimethyl sulfone (DMSO2), ex-creted in the urine of rat were determined quantitatively after administration of DMSO using gas chromatograph equipped with a flame photometric detector (FPD). The results obtained were as follows: 1) DMSO and DMSO2 were well separated using the column packed with 5% polyethylene glycol (20M) on Shimalite W (60-80 mesh). 2) Very small amount of DMSO and DMSO2 could be determined by using gas chromatograph equipped with FPD by which analytical sensitivity of sulphur com-pounds had increased compared with a flame ionization detector (FID) because of its specific response. 3) The rats treated with intraperitoneal injection of 0.55g/kg DMSO excreted 75.21% of DMSO and 13.64% of DMSO2 in the urine during 8 days.
