出版社：National Institute of Occupational Safety and Health
摘要：In order to study the factors which have influenced to β2-microglobulin levels in urine, the effect of hard loading on the concentration of urinary β2-microglobulin was studied. Increase in both actual and corrected β2-microglobulin concentration and slight increase in albumin was observed with volunteers in the urine after marathon running. Maximum excretion of urinary β2-microglobulin was observed 30min after cession of exercise. And increase in actual and corrected β2-microglobulin concentration, and the ratio of β2-microglobulin to creatinine in urine of volunteers loaded 210 steps/min for 1 hour were recognized 30 min after cession of exercise by training machine. Similar result of urinary excretion to β2-microglobulin was obtained with those of creatinine. Concentration of β2-microglobulin in serum had a tendency to increase, but concentration of creatinine in serum was not increased. Results of Sephadex G-100 gel filtrations indicated that urinary β2-microglobulin after exercise, which measured by radioimmunoassay, was contained in the filtrated fraction having molecular weight of approximately 11, 800, suggesting that similar substance to HL-A did not excreted in urine after hard loading.
