出版社：National Institute of Occupational Safety and Health
摘要：Some parameters of heme and drug-metabolism were measured in sham and partially-hepatectomized rats following a single intraperitoneal injection of tin (II) tartrate (2 mg tin/100 g B. Wt.). One day after treatment, tin, in partially hepatectomized rats produced a depression of activities of delta-aminolevulinic acid synthetase and delta-aminolevulinic acid dehydratase, and induction of heme oxygenase. These changes were accompanied by the marked reduction in the levels of cytochrome P-450 and benzo (a) pyrene hydroxylase. Accumulation of tin measured by incorporation of 113tin was 23% less in liver of hepatectomized rats than sham-operated rats, however the accumulation of 113tin in microsomal fraction was much higher in partially hepatectomized rats.
