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  • 标题:二酸化塩素によるポリオウイルスの不活化作用
  • 本地全文:下载
  • 作者:立川 眞理子 ; 濟田 清隆 ; 手塚 雅勝
  • 期刊名称:Journal of Health Science
  • 印刷版ISSN:1344-9702
  • 电子版ISSN:1347-5207
  • 出版年度:1993
  • 卷号:39
  • 期号:6
  • 页码:572-576
  • DOI:10.1248/jhs1956.39.6_572
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The inactivation rate of poliovirus (Lsc, 2ab strain) suspended in a cell maintenance medium (MEM) and in phosphate buffer salt solution (PBS) with chlorine dioxide (ClO2), and chlorite ion (ClO2-), of 0.4, 1.0 and 2.0 mg/l as available chlorine were studied at pH 7 and 20°C. The residual ClO2 and ClO2- formed in the test solution were determined. The decrease of residual ClO2 and the formation of ClO2- in MEM virus suspension were greater than those in PBS virus suspension. In the lower concentration of ClO2 (0.4 mg/l), the decrease of ClO2 in MEM virus suspension resulted in a slower inactivation. With 2.0 mg/l of ClO2, 99% of the virus was inactivated in about 2 min in both virus suspensions. Chlorite ion (2.0 mg/l) had little effect on the inactivation of the virus in 15 min contact. The inactivation rate with 2.0 mg/l of ClO2 was almost the same with that with 0.4 mg/l of HOCl reported in a previous paper. The similar inactivation efficiency may be due to almost the same redox potentials (E0 (V)) of ClO2 and HOCl, and due to the equal oxidizing capacities of 2.0 mg/l of ClO2 and 0.4 mg/l of HOCl in the test solution in the neutral pH range.
  • 关键词:virus inactivation;chlorine dioxide;chlorite ion;virus suspension;hypochlorous acid
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