出版社：National Institute of Occupational Safety and Health
摘要：An experimental study on acute methyl bromide poisoning was carried out in rabbits with subcutaneous injection of the oiled poison which was prepared by dissolving methyl bromide into olive oil. Among the toxicological pictures caused by methyl bromide in rabbits paralysis of the hind limbs, leaving off drinking and reduction of urine seemed to be the char-acteristic signs of this poisoning. Subcutaneous dosage of the oiled poison (50 mg of methyl bromide per kg) to rabbits resulted in a sharp elevation of blood free bromide level which indicated de-composition of methyl bromide, and a marked reduction of platelet count, blood serotonin level and blood water. After these changes free bromide level decreased very slowly in a long period of time, but the other three recovered to their values before dosage within 24 hours. From the fact that the toxicological pictures recovered with those three changing patterns, it was inferred that the toxic effects produced by the injected poison were due to methyl bromide itself and not to its decomposition products. More-over there was a linear relationship between the dose amount and the net decrease in platelet count or blood water per cent at 5 hours after injection of methyl bromide. Consequently the determinations of platelet count, blood serotonin level and blood water per cent were expected to be useful for, the diagnosis of the methyl bromide poisoning in its early stages.
