出版社：National Institute of Occupational Safety and Health
摘要：In the previous papers, the oxidation mechanism of oxyhaemoglobin by sodium nitrite and the effects of various substances on the oxidizing reaction were investiga-ted. In the present paper, the effect of phenylhydrazine on the oxidation of oxy-haemoglobin was studied parallel with the haematological change. In the poisoned rabbits, the decrease of the red blood cells and the formation of Heinz-bodies were observed. At the same time, the oxidation rate of oxyhaemoglobin prepared from the poisoned rabbits was found to be notably reduced with increasing dose of the poison. The change of the oxidation rate was further ascertained by the experiments in vitro, although there were some differences between the results in vivo and in vitro. The measurement of the oxidation rate of oxyhaemoglobin prepared from the blood of animals exposed to poisonous substances, which cause the blood changes, seems to be useful for the early detection of the poisoning.
