出版社：National Institute of Occupational Safety and Health
摘要：The effect of administration of cadmium was investigated on the changes of the contents of sulfhydryl (SH) group and of protein in various tissues of mice after development of a simple method for the determination of SH group. A slight increase of SH group per unit weight of kidney was observed in the supernatant of homogenate which was obtained from mice exposed to cadmium as compared with the level of control. The increased value in the content of SH group was magnified when the proteinsof kidneys of both mice groups were fractionated by alcohol-chloroform and zinc fractionation method. When the mice were bred for seven months with a drinking water containing 0.8mM cadmium acetate, about 7 fold increase in the content of SH group and 4 fold increase in the specific SH group value were observed in this final fraction. It was concluded that the determination of SH group, especially by the simple method, would be a reliable biochemical parameter for cadmium exposure.
