出版社：National Institute of Occupational Safety and Health
摘要：Eight and 24 hr after the single inhalation of the vapor, CCl4 deposited mostly in the adipose tissue in the rats. Carbon tetrachloride disappeared from the tissue very rapidly leaving less than one twentieth of 2 hr value at 48 hr. Groups of rats were exposed to 10, 50 and 100 ppm of CC14 vapor 3 hr a day for as long as 6 to 8 weeks. Triglycerides of the liver increased markedly in 50 and 100 ppm groups and very slightly in 10 ppm, showing the striking correlation between the level of CC14 and the amount of triglycerides accumulated. However, in the range of CC14 level adopted, the effect of the repetition of the inhalations was limited and there was no progressive or cumulative change in the amount of hepatic triglycerides. The level of CC14 in adipose tissue also correlated well with the concentration of the vapor, but its accumulation after repeated exposures was not remarkable. Notwith- standing the presence of marked fatty metamorphosis of the liver, serum transaminases remained in the normal range.
