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  • 标题:Association of Alcohol Consumption with Increase in Aortic Stiffness: A 9-Year Longitudinal Study in Middle-Aged Japanese Men
  • 本地全文:下载
  • 作者:Noriyuki NAKANISHI ; Haruhito KAWASHIMO ; Koji NAKAMURA
  • 期刊名称:Industrial Health
  • 印刷版ISSN:0019-8366
  • 电子版ISSN:1880-8026
  • 出版年度:2001
  • 卷号:39
  • 期号:1
  • 页码:24-28
  • DOI:10.2486/indhealth.39.24
  • 出版社:National Institute of Occupational Safety and Health
  • 摘要:A 9-year longitudinal study was performed to prospectively examine the association falcohol consumption with development of aortic stiffness in 1121 aortic stiffness-free [aortic pulse wave velocity (PWV) of less than 8.0 m/sec] Japanese men aged 35 to 59 years without definite hypertension, hypercholesterolemia, or diabetes. 274 men developed aortic stiffness (aortic PWV of 8.0 m/sec or more) during 8872 person-years follow-up. After controlling for potential predictors of aortic stiffness, the relative risk for increased aortic stiffness compared with non-drinkers was 1.01 [95% confidence interval (CI): 0.62-1.64] for those who drank 0.1 to 22.9 g/day of ethanol, 1.71 (95% CI: 1.12-2.60) for those who drank 23.0 to 45.9 g/day of ethanol, 1.79 (95% CI: 1.18-2.71) for those who drank 46.0 to 68.9 g/day of ethanol, and 2.09 (95% CI: 1.35-3.26) for those who drank 69.0 or more g/day of ethanol (P for trend < 0.001). These results suggest that alcohol consumption is closely associated with development of aortic stiffness.
  • 关键词:Pulse wave velocity;Aortic stiffness;Alcohol;Longitudinal study;Middle-age;Japanese men
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