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  • 标题:CYTOKINETIC AND CYTOGENETIC CHANGES IN CULTURED HUMAN LEUCOCYTES AND HELA CELLS INDUCED BY BENZENE
  • 本地全文:下载
  • 作者:Akira KOIZUMI ; Yuriko DOBASHI ; Yasukazu TACHIBANA
  • 期刊名称:Industrial Health
  • 印刷版ISSN:0019-8366
  • 电子版ISSN:1880-8026
  • 出版年度:1974
  • 卷号:12
  • 期号:1-2
  • 页码:23-29
  • DOI:10.2486/indhealth.12.23
  • 出版社:National Institute of Occupational Safety and Health
  • 摘要:Action of benzene on human leucocytes and on HeLa cells were examined from cytokinetic and cytogenetic points of view. Dose-response type analysis revealed that decreased DNA synthesis of cultured human leucocytes and of HeLa cells were re-markable in dose level of 2.2×10-3 M of benzene. As far as chromosome aberrations of cultured human leucocytes were concerned, gaps and breaks were observed in dose levels of both 2.2×10-3 M and 1.1×10-3 M of benzene.
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