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  • 标题:NEUROLOGICAL SYMPTOMS AND MERCURY CONCENTRATION IN THE BRAIN OF MICE FED WITH METHYLMERCURY SALT
  • 本地全文:下载
  • 作者:Tsuguyoshi SUZUKI ; Tomoyo MIYAMA
  • 期刊名称:Industrial Health
  • 印刷版ISSN:0019-8366
  • 电子版ISSN:1880-8026
  • 出版年度:1971
  • 卷号:9
  • 期号:1-2
  • 页码:51-58
  • DOI:10.2486/indhealth.9.51
  • 出版社:National Institute of Occupational Safety and Health
  • 摘要:A hypothesis on the critical concentration of mercury in the brain, which is neces-sary to induce neurological symptoms, was tested again by feeding of methylmercury chloride to mice. As well as in the previous experiment; single or repeated peroral administration of methylmercury chloride to mice, death followed the occurrence of neurological symptoms, when the accumulated amount of mercury was more than 30 μg Hg/g. The most sensitive, namely earliest, symptom; the lessening of the head mainte-nance on horizontal position on being hung with the tail was noticed at a brain con-centration of 10 μg Hg/g. The lowest daily dose group of 10 μg Hg/g of diet did not show the loss of body weight and neurological symptoms during the observation period up to the 41st day of mercury feeding.
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