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  • 标题:Two Flavonoids from the Leaves of Mours alba Induce Differentiation of the Human Promyelocytic Leukemia (HL-60) Cell Line
  • 本地全文:下载
  • 作者:Sun Yeou KIM ; Jian Jun GAO ; Hee Kyoung KANG
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2000
  • 卷号:23
  • 期号:4
  • 页码:451-455
  • DOI:10.1248/bpb.23.451
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Two flavonoids, quercetin-3-O-β-D-glucopyranoside (1) and quercetin-3, 7-di-O-β-D-glucopyranoside (2), were isolated from the leaves of Mours alba (Moraceae). These two flavonoids exerted a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) at the concentration of 2×10-4 M. Compound 2 also induced differentiation of the HL-60 cell line to express CD 66b and CD 14 antigens. These flavonoids exhibited significant free radical scavenging effects on 1, 1-diphenyl-2-picyl-hydrazyl radical.
  • 关键词:mulberry leaf;flavonoid;differentiation
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