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  • 标题:Studies on Inhibitory Activities of Fukiic Acid Esters on Germination, α-Amylase and Carboxypeptidase A
  • 本地全文:下载
  • 作者:Genjiro KUSANO ; Masayuki TAKAHIRA ; Makio SHIBANO
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1998
  • 卷号:21
  • 期号:9
  • 页码:997-999
  • DOI:10.1248/bpb.21.997
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Fukinolic acid (1) and cimicifugic acid A (2), caffeic acid analogs, as well as rosmarinic acid (3) and caffeic acid (4) showed inhibition on seed germination and seeding growth. The potency of 1 and 2 was comparable with that of 3. Compounds 1 and 2 also showed strong inhibitory activites as well as 3 and 4 on α-amylase. The activity of 1 was higher than that of acarbose used as a positive control, and its 50% inhibitory concentration (IC50) was 2.41×10-5 M. Compounds 1 and 2 also showed inhibitory activities strong as 3 and stronger than 4 on carboxypeptidase A. The activities of 1 and 2 were higher than that of 1, 10-phenanthroline used as a positive control.
  • 关键词:Cimicifuga simplex;caffeic acid-related compound;fukiic acid-related compound;seed germination-inhibitory activity;α-amylase inhibition;carboxypeptidase A inhibition
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