标题：Inhibitory Effects of Shouseiryu-to on Two-Stage Carcinogenesis. II.Anti-tumor-promoting Activities of Lignans from Asiasarum heterotropoides var. mandshuricum
摘要：Two lignans, asarinin (6) and xanthoxylol (7), were isolated from the radix of Asiasarum heterotropoides var. mandshuricum, which consist of a kampo prescription, Shouseiryu-to, as inhibitors of Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). These lignans also exhibited remarkable inhibitory effects on a two-stage carcinogenesis test of mouse skin and pulmonary tumors. Furthermore, it was confirmed that these hydrophobic lignans dissolved in the water decoction of Shouseiryu-to, and these lignans might be among the active consituents of this kampo prescription in terms of its anti-tumor-promoting activity.
关键词：anti-tumor-promoter;lignan;asarinin;xanthoxylol;Asiasarum heterotropoides var. mandshuricum;Shouseiryu-to
