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  • 标题:Concanamycin B, a Vacuolar H+-ATPase Specific Inhibitor Suppresses Bone Resorption in Vitro
  • 本地全文:下载
  • 作者:JeTae WOO ; Yasuo OHBA ; Kahori TAGAMI
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1996
  • 卷号:19
  • 期号:2
  • 页码:297-299
  • DOI:10.1248/bpb.19.297
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Effects of concanamycin B, a specific inhibitor of the vacuolar type H+-ATPase (V-ATPase), on the stimulation of bone resorption induced by parathyroid hormone (PTH) were examined in vitro. Concanamycin B was found to inhibit PTH-stimulated osteoclastic pit formation and to suppress the acidification of vacuolar organelles by V-ATPase in the osteoclasts. PTH-stimulated 45Ca release from prelabelled chick embryonic calvariae was also inhibited by concanamycin B in a dose-dependent manner. These results suggest that osteoclastic acidification of lacunae by V-ATPase plays an essential role in mineral dissolution and degradation of the organic matrix during bone resorption.
  • 关键词:concanamycin B;vacuolar H+-ATPase inhibitor;bone resorption
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