标题：Studies on Thermophile Products. VII. Effect of 1, 3-Di-14-methylpentadecanoyl Glycerol and Its Related Isofatty Acids on T Cell Proliferation in Vitro
摘要：It has been found that Bacillus stearothermophilus UK563-derived immunosuppressant fraction (Fr. 5-B) consists of 1, 3-diacylglycerols with saturated iso- and anteiso-type fatty acids (C14 : 0-C18 : 0) as major components. The compound, 1, 3-di-14-methylpentadecanoyl glycerol (1, 3-diiso C16 : 0 G), was synthesized and its effect on T cell proliferation was investigated together with its related isofatty acids. While 1, 3-diiso C16 : 0 G, iso C16 : 0, iso C17 : 0, iso C17 : 0methyl ester (OMe) and anteiso C17 : 0 OMe suppressed the mixed lymphocyte reaction (MLR) of C57BL/6 against BALB/c mice, iso C15 : 0, 1, 3-acylglycerols with normal C16 : 0, C16 : 1 and C18 : 0 did not, suggesting that the presence of isofatty acids with a certain chain length may be essential for the suppression of MLR. 1, 3-Diiso C16 : 0 G and iso C16 : 0 strongly inhibited the autologous MLR of mesenteric lymph node cells against self-antigen presenting cells in MRL/MpJ-lpr/lpr (MRL/lpr) mice, but had no effect on concanavalin A-induced T cell proliferation.
