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  • 标题:Carbonic Anhydrase Activators. VII. Isozyme II Activation by Bisazolyl-methanes, -ethanes and Related Azoles
  • 本地全文:下载
  • 作者:Claudiu T. SUPURAN ; Alexandru T. BALABAN ; Pilar CABILDO
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1993
  • 卷号:16
  • 期号:12
  • 页码:1236-1239
  • DOI:10.1248/bpb.16.1236
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:A correlation was found between the carbonic anhydrase II activating power and the pKa values for a series of azoles, bisazolylmethanes and bisazolylethanes. Strong activations were found for compounds with pKa's in the interval 6.5-8.0. The mechanism of action for such activators is discussed.
  • 关键词:carbonic anhydrase;isozyme II;azole;bisazolyl-methane/ethane;pKa
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