摘要：Our previous study showed that A2 allele of dopamine D2(DRD2)Taql A polymorphism related to smoking habits, which was opposed to the results of studies for Caucasians.In order to confirm our finding, a similar study was conducted for the first-visit outpatients of Aichi Cancer Center Hospital, who participated in HERPACC-II(Hospital-based Epidemiologic Research Program at Aichi Cancer Center II).Among consecutive 1, 577 first-visit patients between November 2000 and February 2001, 800 patients provided a 7m1 of peripheral blood.Smoking habit data were available for 798 participants. Excluding five participants aged < 20 years or ≥080 years, the remaining 793 participants(346 males and 447 females)were analyzed.The DRD2 genotype was determined by a new method, polymerase chain reaction with confronting two-pair primers(PCR-CTPP).In males, current smokers were 35.3% of individuals with A1A1 genotype, 43.1% of individuals with A1A2 genotype, and 57.0% of individuals with A2A2 genotype, while in females, they were 19.6%, 14.6%, and 10.9%, respectively.Age-adjusted odds ratio(OR)of current smoking relative to A1A1 was 1.61(95% confidence interval, 0.71-3.46)for A1A2 and 2.32(1.02-5.29)for A2A2 in males, and 0.72(0.32-1.61)and 0.51(0.22-1.18)in females, respectively.The present study indicated that Japanese males with A2A2 genotype have a higher risk of being current smokers.No association for Japanese females suggested that female smoking behavior is differently affected in biological and/or psychological manner. J Epidemiol 2002;12:297-304.
