摘要：The association of the severity of coronary atherosclerosis with hypertension and dyslipidemia, independent of other known coronary risk factors, was examined in 313 men and 155 women who underwent coronary angiography. The severity of coronary atherosclerosis was quantified using Gensini's scoring system. The following criteria were used to define dyslipidemia : hypercholesterolemia (total serum cholesterol concentration ≥220 mg/dl), hypertriglyceridemia (serum triglyceride concentration ≥150 mg/dl), and low HDL-cholesterolemia (serum HDL-cholesterol concentration<40 mg/dl). In men, age, total cholesterol, fasting blood sugar, uric acid, and plasma fibrinogen levels were significantly higher inpatients with coronary atherosclerosis than in those without. Significantly higher frequency of hypertension and lower levels of HDL-cholesterol were also found in male patients with coronary atherosclerosis. In women, age, total cholesterol, fasting blood sugar, and plasma fibrinogen levels were significantly higher in patients with coronary atherosclerosis than in those without. No significant interaction between hypertension and each dyslipidemia was found after adjustment for the other coronary risk factors ; only hypercholesterlemia in men was significantly associated with coronary atherosclerosis. However, the degree of coronary atherosclerosis was most severe among patients with both hypertension and hypercholesterolemia in both sexes. The combination of hypertension and hypercholesterolemia seems to be important in the progression of coronary atherosclerosis. J Epidemiol, 1995; 5 : 17-22.
