首页    期刊浏览 2024年12月03日 星期二
登录注册

文章基本信息

  • 标题:Enhancement of Lipid Peroxidation by Chromium(IV) and Chromium(V) is Remarkable Compared to That by Chromium(VI) and is Effectively Suppressed by Scavengers of Reactive Oxygen Species
  • 作者:Yasuji Hojo ; Kiyoko Nishiguchi ; Sadahiro Kawazoe
  • 期刊名称:Journal of Health Science
  • 印刷版ISSN:1344-9702
  • 电子版ISSN:1347-5207
  • 出版年度:2000
  • 卷号:46
  • 期号:2
  • 页码:75-80
  • DOI:10.1248/jhs.46.75
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:It is assumed that oxidative stress due to reactive oxygen species (ROS) such as superoxide anion (·O2 -), hydrogen peroxide (H2O2) and hydroxyl radical (·OH) may result in oxidative damage to lipids and DNA. On the other hand, chromium(VI) compounds, potent carcinogens, are known to induce lipid peroxidation. However, it is not clear how Cr(VI) induces lipid peroxidation and DNA damage. In this article, in order to clarify the mechanism by which Cr(VI) enhances lipid peroxidation, the lipid-peroxidizing activity of Cr(IV) and Cr(V), Cr intermediates possibly produced in the reductive metabolism of Cr(VI), were compared with that of Cr(VI) and Cr(III), and the inhibitory effects of ROS scavengers on lipid peroxidation induced by Cr(IV) and Cr(V) were examined by incubating mouse liver homogenate with Cr and scavenger compounds. Cr(IV), Cr(V) and Cr(VI) compounds effectively enhanced lipid peroxidation of homogenate in this order. The lipid-peroxidizing effect of Cr(IV) was suppressed more remarkably by superoxide dismutase, catalase and formate, specific scavengers of ·O2 -, H2O2 and ·OH, respectively, than that of Cr(V), which is indicative of the involvement of ·O2 -, H2O2 and ·OH in lipid peroxidation stimulated by these Cr species. These results suggest the possible participation of Cr(IV), Cr(V), ·O2 -, H2O2 and ·OH in Cr(VI)-enhanced lipid peroxidation.
  • 关键词:mouse liver homogenate
Loading...
联系我们|关于我们|网站声明
国家哲学社会科学文献中心版权所有