期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1998
卷号：44
期号：5
页码：697-703
DOI：10.3177/jnsv.44.697
出版社：Center for Academic Publications Japan
摘要：Background: Peroxidatively modified low-density lipopro-tein (LDL) may contribute to the atherosclerotic process; therefore, pro-tecting LDL against peroxidation may reduce or retard the progression of atherosclerosis. We evaluated the effect of α-tocopherol on copper-catalyzed LDL peroxidative modification. Methods: The protective effects of a-tocopherol on copper-catalyzed LDL peroxidative modification were examined by measurement of the concentration of lipid hydroperoxides in LDL and by the provision of LDL cholesterol to lymphocytes via the LDL receptor-mediated pathway. Results: The measurement of concentration of lipid hydroperoxides in LDL showed that a-tocopherol inhibited the peroxidative modification of LDL. Also, α-tocopherol preserved the ability of LDL to be recognized by LDL receptors in peripheral blood lymphocytes to the same extent as native LDL. Conclusion: These findings indicate that α-tocopherol may protect LDL against peroxidative modification, maintaining its ability to act as a ligand for LDL receptors in vivo.
