首页    期刊浏览 2024年11月23日 星期六
登录注册

文章基本信息

  • 标题:Effects of Dietary n-3/n-6 and Polyunsaturated Fatty Acid/Saturated Fatty Acid Ratios on Platelet Aggregation and Lipid Metabolism in Rats
  • 本地全文:下载
  • 作者:Norihiro YAMADA ; Toshichika TAKITA ; Masahiro WADA
  • 期刊名称:Journal of Nutritional Science and Vitaminology
  • 印刷版ISSN:0301-4800
  • 电子版ISSN:1881-7742
  • 出版年度:1996
  • 卷号:42
  • 期号:5
  • 页码:423-434
  • DOI:10.3177/jnsv.42.423
  • 出版社:Center for Academic Publications Japan
  • 摘要:We studied the effects of dietary lipids on platelet aggregation and lipid metabolism in rats by varying the n -3/ n -6 ration while maintaining the polyunsaturated fatty acid/saturated fatty acid (P/S) ratio fixed, and vice versa. After two weeks, the platelet counts decreased as the dietary n -3/ n -6 ratio rose, and platelet aggregation was sufficiently suppressed at the ratio of 0.2. Differences in the dietary P/S ratio, however, did not affect either the platelet counts nor platelet aggregation. As the dietary n -3/ n -6 ratio rose, the proportion of arachidonic acid (AA) in the plasma and the phospholipids (PL) of the platelets and aorta decreased gradually, whereas the proportion of eicosapentaenoic acid (EPA) in each tissue increased gradually. The proportion of EPA was higher in the platelets than in the aorta, while that of docosahexaenoic acid (DHA) was higher in the latter. The production of platelet thromboxane A2 (TXA2) and aortic prostacyclin (PGI2) showed sharp declines, from the values for the n -3/ n -6 ratio of 0.02 (control) to those for 0.5. These results suggest that the n -3/ n -6 ratio of dietary fats necessary to ensure the suppression of platelet aggregation in normal rats would be at least 0.2 and no more than 0.5.
  • 关键词:n-3/n-6 ratio;platelet aggregation;arachidonic acid;eicosanoids;eicosapentaenoic acid;docosahexaenoic acid
国家哲学社会科学文献中心版权所有