期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1994
卷号：40
期号：1
页码：49-61
DOI：10.3177/jnsv.40.49
出版社：Center for Academic Publications Japan
摘要：Wistar rats (4-week-old) were administered with streptozo-tocin (45mg/kg) through tail veins. After 3 months, diabetic rats were divided into 2 groups. One group (EPA group, n =16) was fed a lipid-free diet (90%, w/w) plus lard (8%) and 90% pure eicosapentaenoic acid ethyl ester (2%) for 6 months. The other group (control group, n =16) was fed in the same way except that eicosapentaenoic acid ethyl ester was replaced by safflower oil. Twenty-four-hour urine was collected just before starting the experimental diets and during the 6-month experimen-tal period at monthly intervals. There were no differences in food intake and body weight between the two groups throughout the experiment. The mean microalbuminuria of the EPA group became significantly lower than that of the control group after 4 months on the diets through the end of the study (6 months). The mean microalbuminuria levels at the end of the study were 1.38mg/day in the EPA group ( n =9) and 5.19mg/day in the control group ( n =6) (p<0.01). Eicosapentaenoic acid administra-tion might retard the progression of diabetic nephropathy by reducing microalbuminuria.
