期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1993
卷号：39
期号：5
页码：537-543
DOI：10.3177/jnsv.39.537
出版社：Center for Academic Publications Japan
摘要：An anti-obesity effect was observed for cholest-4-en-3-one (cholestenone) which is an intestinal catabolite of cholesterol. Body weight gain and body fat accumulation of CDF 1 mice were inhibited by 0.5% dietary exposure to this chemical. Dose response for the effect of cholestenone was found to increase as the dose rose from 0.1 to 0.3% and 0.500. No obvious anomaly due to consumption of cholestenone was detected by necropsy and clinical observation. The mechanism of this effect of cholestenone is not known at present, but it was not due to anorexia.
