期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2003
卷号：49
期号：3
页码：210-213
DOI：10.3177/jnsv.49.210
出版社：Center for Academic Publications Japan
摘要：The effect of dietary supplementation with n -3 fatty acids, primarily docosa-hexaenoic acid (DHA) With high purity, on the fatty acid composition, especially very-long-chain fatty acids (VLCFA) longer than DHA, with four or six double bonds, in the rod outer segment (ROS) membranes of young Sprague-Dawley rats was investigated. After several weeks of feeding, diets high in n -3 fatty acids increased the DHA level significantly, while there were decreased levels of most n -6 fatty acids, such as arachidonic acid and 22:5 n -6. Six kinds of VLCFA Were detected by gas chromatography-mass spectrometry (GC-MS). Feeding a high n -3 fatty acid diet significantly increased the content of some n -3 VLCFAs such as 26:4 n -3 and 30:4 n -3 in ROS membranes, but not all detected n -3 VLCFAs. This study demonstrates that the dietary level of n -3 fatty acids not only affects the level of DHA, but also the levels of VLCFA in ROS membranes.
