标题：Bone Marrow and Serum Concentrations of 25-Hydroxy vitamin D, 24, 25-Dihydroxyvitamin D, and 1α, 25 Dihydroxyvitamin D in Patients with Leukemia and Normal Subjects
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1989
卷号：35
期号：4
页码：211-223
DOI：10.3177/jnsv.35.211
出版社：Center for Academic Publications Japan
摘要：Concentrations of 25-hydroxyvitamin D (25-OH-D), 24, 25dihydroxyvitamin D [24, 25 (OH)2D], and 1α, 25-dihydroxyvitamin D [1, 25(OH)2D] in bone marrow and serum of patients with leukemia and normal subjects were assayed. There were highly significant correlations between the bone marrow and serum concentrations of the respective vitamin D metabolites. Especially, the concentrations of 25-OH-D and 1, 25 (OH)2D in the bone marrow gave very similar values to those in serum. This is a big advantage in controlling the bone marrow levels of vitamin D metabolites in patients with leukemia, because doctors can calculate the bone marrow levels from the serum levels of the respective vitamin D metabolites without bone marrow aspiration. When 1 ochydroxyvitamin D3 (1α-OH-D3) was administered orally to eight patients with leukemia, clinical conditions were improved in seven patients: four complete remissions (CR), one partial response (PR), and two minor responses (MR) without severe hypercalcemia. The results suggest that the therapy with 1α-OH-D3 is fairly effective for curing human leukemia although it is not dramatic.
关键词：leukemia;bone marrow;vitamin D;25-hydroxyvitamin D;24, 25-dihydroxyvitamin D;1 α, 25-dihydroxyvitamin D
