期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1989
卷号：35
期号：3
页码：163-170
DOI：10.3177/jnsv.35.163
出版社：Center for Academic Publications Japan
摘要：We showed elevated plasma levels of branched-chain amino acids, a-ketoacids, a-hydroxyacids in thiamin-deprived rats, which had decreased liver thiamin levels (2.4% of control) after 4 weeks of feeding of thiamin-deficient diet. The ratios of mean levels of these acids in thiamin-deficient rats to those in control rats were as follows: total branched-chain amino acids 1.6; total branched-chain α-ketoacids 2.7; total branched-chain a-hydroxyacids 3.6; pyruvic acid 1.6. The plasma level of total branched-chain a-hydroxyacids was correlated to liver thiamin concentration (γ=-0.67, p <0.01), but those of the other two acids were not correlated. Although the increased levels of branched-chain acids in thiamin-deprived rats were less remarkable than those of ill patients with maple syrup urine disease, they reflect the reportedly decreased branched-chain a-ketoacid dehydrogenase activities (about 40% of control), and we discussed whether the toxic effects of individual branched-chain acid could be demonstrated by its administration to the thiamin-deprived rats.
