标题：Effects of Indigestible Dietary Bulk and Short Chain Fatty Acids on the Tissue Weight and Epithelial Cell Proliferation Rate of the Digestive Tract in Rats
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1986
卷号：32
期号：4
页码：355-362
DOI：10.3177/jnsv.32.355
出版社：Center for Academic Publications Japan
摘要：Influences of indigestible dietary bulk (kaolin), short chain fatty acids (SCFA), and their interaction on the weight and epithelial cell proliferation rate of digestive organs were studied. Rats with an ileal fistula were fed an elemental diet with or without kaolin (10% w/w). They were given a 3 ml SCFA mixture (acetate, propionate, and butyrate; 100, 20, and 60mM, respectively; pH 6.1) or a 3ml NaCl solution (180mM; pH 6.1) via the fistula twice a day for 14 days. Kaolin, but not SOFA, increased full and empty body weight by 14% and 13%, respectively. Kaolin increased the tissue weight, but not relative tissue weight (tissue weight/empty body weight), of the forestomach, distal colon, liver and heart by 6-14%. SCFA, independent of the presence of kaolin, increased the weight and the relative weight of the cecum, both by 15%. SCFA, but not kaolin, increased the cryptal cell production rate in colonic segments by 50-140%. These results indicate that (a) SCFA accelerates epithelial cell proliferation, thereby increasing cecal tissue weight, (b) kaolin stimu-lates body weight gain which is accompanied by a proportional increase in the tissue weight of some digestive organs, and (c) the actions of these factors are independent of each other.
