期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1985
卷号：31
期号：1
页码：1-5
DOI：10.3177/jnsv.31.1
出版社：Center for Academic Publications Japan
摘要：In order to investigate mineral and vitamin D metabolism in obese rats with hyperinsulinemia, plasma calcium and vitamin D meta-bolites were measured in Zucker fa / fa rats. Body weight, plasma insulin, and calcium in fa / fa rats were significantly increased compared to their lean littermates ( p <0.01). However, no significant difference in plasma 25-hydroxyvitamin D (25(OH)D), 24, 25-dihydroxyvitamin D, 1, 25-dihy-droxyvitamin D (1, 25(OH)2D) or the ratio of 1, 25(OH)2D to 25(OH)D was observed between fa/fa rats and their lean littermates. The hypercal-cemia in the rats with hyperinsulinemia, therefore, might be caused by other calcium-regulating hormones or some factors other than 1, 25-(OH)2D. In addition, the hyperinsulinemia associated with obesity may not produce the accelerated conversion from 25(OH)D into 1, 25(OH)2D.
