标题：Effects of Dietary Zinc and Cadmium on Tissue Selenium Concentration and Glutathione Peroxidase Activity in Rats Fed DL-Selenomethionine or Sodium Selenite
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1991
卷号：37
期号：1
页码：29-37
DOI：10.3177/jnsv.37.29
出版社：Center for Academic Publications Japan
摘要：The effects of dietary zinc (Zn) and cadmium (Cd) on tissue selenium (Se) concentration and glutathione peroxidase (GSH-Px) activity were studied in weanling male Wistar rats. One group of rats was fed a purified diet based on casein and sucrose, and the other rats used in a 2×2×2 factorial arrangement of treatment were fed this diet supplemented with 0.1mg Se/kg, either as DL-selenomethionine or sodium selenite and plus 100mg Zn/kg as zinc sulfate or 5mg Cd/kg as cadmium chloride or both for 4 weeks. Se concentrations in plasma, erythrocytes, muscle, heart, and liver were significantly elevated by Zn. Cd significantly decreased Se concentration in muscle. Addition of Zn to the diets markedly increased ( p <0.001) hepatic GSH-Px activity. However, Cd in the diets produced a significant increase ( p <0.001) in erythrocyte GSH-Px activity. These results indicate that Zn level of marginal deficiency(8.6mg/kg diet) can decrease Se availability and a small excess of Zn increases Se availability for hepatic GSH-Px activity.
关键词：selenium;selenite;DL-selenomethionine;zinc;cadmium;rat;bioavailability;glutathione peroxidase;trace elements
