期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1991
卷号：37
期号：Supplement
页码：S25-S33
DOI：10.3177/jnsv.37.Supplement_S25
出版社：Center for Academic Publications Japan
摘要：To evaluate the relationship between cardiac function at rest and the exercise capacity of diabetic patients, left ventricular function and exercise capacity were evaluated in 15 non-insulin-dependent male diabetic patients. Isovolumic relaxation time (IRT) and the PEP/LVET ratio were obtained by simultaneous echophonocardiograms, electrocardiograms, and recordings of the carotid arterial pulse. VO2 at anaerobic threshold was obtained from a cycle ergometer exercise test with expired gas analysis. Patients were divided into two groups: those with IRT<90 msec (Group 1) and those with IRT≥90 msec (Group 2). Group 2 patients had a lower VO2 at anaerobic threshold than Group 1 (Group 1:17.4±3.6, Group 2:12.9±2.5ml/min/kg; M±SD, p <0.05). There was a good correlation between the IRT at rest and ΔHR, defined as the change in heart rate from rest to anaerobic threshold ( r =0.666, p <0.01), and between ΔHR and the beat-to-beat variation in R-R interval at rest ( r =0.637, p <0.02). There was also a good correlation between VO2 at anaerobic threshold and IRT ( r =0.555, p <0.05), and between VO2 at anaerobic threshold and ΔHR ( r =0.858, p <0.01). Our data suggests that both left ventricular diastolic function and cardiac sympathetic nervous system reflexes, reflected by ΔHR, may affect the exercise capacity of diabetic patients. Thus, IRT obtained by a non-invasive method may provide a useful index for cardiovascular response to exercise in diabetic patients without coronary artery disease.
关键词：exercise capacity;anaerobic threshold;cardiac function;autonomic nervous system
