期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1991
卷号：37
期号：Supplement
页码：S113-S118
DOI：10.3177/jnsv.37.Supplement_S113
出版社：Center for Academic Publications Japan
摘要：We investigated the relationship between bone mineral density loss and mean serum phosphate level for one year in 58 men on maintenance hemodialysis who were treated with 1α-hydroxycholecalciferol and calcium bicarbonate. Bone mineral density of the femur head and neck was measured twice, 8 months apart, by dual energy X-ray absorptiometry (Hologic QDR 1000). Patients were divided into two groups according to their mean serum phosphate level during the year of the study. Group A had almost normal serum phosphate levels (mean, <6.0 mg/dl) and group B had hyperphosphatemia (mean, ≥6.0 mg/dl). In group A, the mean bone mineral density was 0.825±0.122 g/cm2 at the beginning of the study and 0.828 ±0.118 g/cm2 8 months later. In group B, these values were 0.787 ±0.167 g/cm2 at the beginning and 0.762 ±0.171 g/cm2 8 months later. Bone mineral density did not decrease in group A, but it decreased significantly in group B ( p <0.01). For all patients, the percent increase in the bone mineral density was inversely correlated with the mean serum phosphate value for the year of the study ( r = -0.274, p <0.05). These results indicate the importance of serum phosphate control in patients on maintenance hemodialysis, even when they are being treated with 1α-hydroxycholecalciferol and calcium carbonate.
关键词：renal osteodystrophy;bone mineral density;1α-hydroxycholecalciferol;calcium carbonate;aluminum
