文章基本信息

标题：Effect of Vitamin A Deficiency on Oxalate Uptake by Rat Intestinal Brush Border Membrane Vesicles (BBMV) and Its Contribution towards Urolithiasis
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作者：Sadhna SHARMA ; Ravinder NARULA ; Ravindra NATH 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1990
卷号：36
期号：6
页码：579-586
DOI：10.3177/jnsv.36.579
出版社：Center for Academic Publications Japan
摘要：The intestinal uptake of [¹⁴C]oxalate, [¹⁴C] glyoxylate, and [¹⁴C] glycolate are studied in brush border membrane vesicles (BBMV) isolated from vitamin A-deficient and pair-fed control rats. The data obtained indicate that oxalate and its precursors are transported across the BBMV by passive diffusion. The intestinal uptake of glyoxylate and glycolate remains unaltered in vitamin A deficiency, while uptake rate of oxalate was significantly increased ( p <0.01) in vitamin A-deficient rats as compared to pairfed controls. In conclusion, the results indicate that vitamin A deficiency leads to hyperabsorption of oxalate through the gut.
关键词：vitamin A deficiency;oxalate uptake;intestinal BBMV;urolithiasis