期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1975
卷号：21
期号：1
页码：39-47
DOI：10.3177/jnsv.21.39
出版社：Center for Academic Publications Japan
摘要：Studies were conducted to evaluate specific dampening of hyperlipo-genesis ( i.e. enhanced lipogenic enzyme activity of the liver in rats refed a high carbohydrate, fat-free diet: F-diet) by exogenous polyunsaturated fatty acids under fixed carbohydrate consumption. In force-feeding of rats with a linoleate-rich diet (F-diet containing 4.5 safflower oil), the lipogenic enzyme activities; fatty acid synthetase (FAS) and malic enzyme (ME), in the liver supernatantt were found to be significantly lower than those in rats force-fed only an F-diet ( p <0.02), under conditions of identical consumption of carbohydrate. Among the various methylesters of unsaturated fatty acids administered by gastric intubation at a dose of 0.3g per 100g body weight, arachidonate was most potent in bringing about a significant reduction of hyper-lipogenesis without seriously affecting food intakes. During the same three-day experimental period, fatty acid GLC spectra in both the liver and plasma lipids reflected the exogenous input of PUFA. Plasma total fatty acid concentration (mainly triglyceride) significantly de-creased in the arachidonate group ( p <0.01).
