期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1987
卷号：33
期号：4
页码：281-288
DOI：10.3177/jnsv.33.281
出版社：Center for Academic Publications Japan
摘要：The effects of dietary addition of some xenobiotics on tissue levels of copper and α-tocopherol in rats were studied with special reference to serum cholesterol. The chemicals added here were 0.05 polychlorinated biphenyls (PCB), 0.3% caffeine, 0.05% 1, 1, l-trichloro-2, 2-bis( p -chlorophenyl)ethane (DDT), 0.3% flavone, 0.3% chloretone, 0.3% 2-tert-butyl-4-methoxyphenol (BHA), 0.15% sodium Phenobarbital, 0.15% phenytoin, 0.2% sodium pentobarbital, and 0.15% phenylbutazone. Of these chemicals, dietary PCB, caffeine, DDT, flavone, chloretone, BHA and phenytoin raised the level of copper in liver, kidney, or serum. Serum a-tocopherol and cholesterol also increased with the additive or synergistic effects on these metabolisms. Moreover, these combined addition of dietary 0.02% PCB with 0.2% BHA seemed to cause additive or synergistic effects on these metabolism. Moreover, these chemicals raised serum ceruloplasmin activity. In general, serum copper, ceruloplasmin activity and a-tocopherol were correlated with serum cholesterol in these dietary manipulations.
