期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1982
卷号：28
期号：2
页码：69-75
DOI：10.3177/jnsv.28.69
出版社：Center for Academic Publications Japan
摘要：In rat liver, 90% of the aspartate aminotransferase is present as the holoenzyme. In pyridoxine deficiency, the ratio of holoenzyme activity to total activity is markedly reduced, but after pyridoxine injection it was found to rapidly increase, although the total enzyme activity remained low for a few days. The activities of aspartate aminotransferase isozymes in pyridoxine-deficient rat tissues and the effect of pyridoxine treatment on their activities were examined. The intestinal enzyme acti-vities of pyridoxine-deficient rats were readily reconstituted in the presence of pyridoxal phosphate in vitro, but the enzyme activities in liver and muscle in the deficient rats required several days for complete recovery, suggesting that active enzyme was synthesized de novo in these tissues.
关键词：aspartate aminotransferase;B6 deficiency;inactive enzyme;reconstitution of Asp AT;pyridoxine injection
