期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1982
卷号：28
期号：1
页码：57-66
DOI：10.3177/jnsv.28.57
出版社：Center for Academic Publications Japan
摘要：In rats fed for 2 weeks on a 10% casein diet suaolemented with 5% leucine, the hepatic NAD content was lowered when comparing with the control rats pair-fed on the 10% casein diet. The hepatic NAD glycohydrolase [EC 3.2.2.5] activity increased by 25% in the leucine-supplemented diet-fed rats and by 40% in the nicotinic acid-free diet-fed rats. The hepatic NAD glycohydrolase activity in the rats fed on the non-protein diet freely for 1 week was elevated by 60% compared to the rats fed on the 18% casein diet. The hepatic NAD content in the former animals was significantly lower than that in the latter. The 70% casein diet caused changes in neither hepatic NAD content nor NAD glycohydrolase activity. These results indicated an inverse relationship between hepatic NAD content and NAD glycohydrolase activity.
关键词：dietary excess leucine;dietary protein level;rat hepatic NAD level;rat hepatic nicotinamide level;rat hepatic NAD glycohydrolase;urinary N1-methylnicotinamide
