标题：TIME-COURSE OF CHANGES OF LIVER TRYPTOPHAN PYRROLASE (TRYPTOPHAN OXYGENASE) AND LIVER AND KIDNEY GLUCOSE-6-PHOSPHATASE IN RATS SHIFTED FROM HIGH- TO ZERO-PROTEIN DIETS
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1980
卷号：26
期号：3
页码：261-269
DOI：10.3177/jnsv.26.261
出版社：Center for Academic Publications Japan
摘要：Time-courses of changes in the activities of liver and kidney glucose-6-phosphatase [EC 3. 1. 3. 9] and hepatic tryptophan pyrrolase [EC 1. 13. 1. 12; TPO] in rats pre-fed high-protein diets for 5 days and then shifted to zero-protein diets were studied. Liver glucose-6-phosphatase activity decreased 1 day after the dietary shift but then increased and remained significantly higher than the O day value for the next 2 days. Changes in liver glycogen were found to be intimately and inversely related to liver glucose-6-phosphatase activity. Changes in kidney glucose-6-phosphatase activity paralleled the pattern of changes observed in liver activity. An initial decrease in TPO activity was followed by increased enzyme activity up to the 3rd day of the dietary shift. Later there was a rapid fall in tryptophan pyrrolase activity. Changes observed in these specific enzyme proteins differed from those observed in total tissue proteins. Alterations in the activities of these enzymes and changes in other parameters are compared with those observed earlier with the reverse type of dietary shift.
