期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1980
卷号：26
期号：2
页码：183-188
DOI：10.3177/jnsv.26.183
出版社：Center for Academic Publications Japan
摘要：The inhibitory effects of β-sitosterol on intestinal cholesterol absorption were studied by means of a dual isotope plasma ratio method ( in vivo ), which is a new technique for the measurement of cholesterol absorption, as well as a ligated-loop method ( in situ ). The results obtained were as follows: 1. The absorption of β-sitosterol itself was significantly less than cholesterol. Cholesterol was selectively absorbed from rat intestine. 2. When 100 to 1, 000μg of β-sitosterol were added to the dose solution containing 10μg of cholesterol, cholesterol absorption by the in vivo experiment decreased with the increase of additional β-sitosterol. 3. A similar inhibitory effect of β-sitosterol was observed by the in situ ligated-loop method. These results suggest that β-sitosterol actually inhibits cholesterol absorption in the physiological state of an animal.
