期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1974
卷号：20
期号：3
页码：215-225
DOI：10.3177/jnsv.20.215
出版社：Center for Academic Publications Japan
摘要：The accumulation of lipid in the liver was observed in rats fed a non-protein diet supplemented with methionine, but further supplement of threonine partially prevented liver lipid accumulation. Supplements of leucine, phenylalanine or histidine slightly lowered the liver lipid accumulation of rats fed the nonprotein diet containing methionine. On the other hand, free fatty acid in the plasma was not changed when rats were fed the nonprotein diet supplemented with methionine. No difference Was observed in the plasma lipoprotein of rats fed a non-protein diet supplemented with or without methionine. However, the threonine supplement increased the total esterified fatty acid in the plasma lipoprotein ( d <1.006) of rats fed a nonprotein diet containing methionine. A slight decrease was observed in the β-lipoprotein of rats fed the nonprotein diet supplemented with methionine. When injected with Triton WR-1339, the total esterified fatty acid content remarkably increased in the plasma of rats fed the nonprotein diet supplemented with methionine as well as the nonprotein diet, and the plasma β-lipoprotein of Triton WR-1339 treated rats was also increased in both groups. Therefore, it was assumed from the results that the transport of lipid from liver into blood is not inhibited in this type of fatty liver. At present, the cause of the fatty liver due to methionine supplementation to a nonprotein diet is not clear. However it seems un-likely that the inhibition of the lipoprotein transport from the liver to the blood plasma is the main reason for it.
