期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2005
卷号：51
期号：2
页码：104-109
DOI：10.3177/jnsv.51.104
出版社：Center for Academic Publications Japan
摘要：To investigate the incorporation of acetate into fatty acids and their turnover, the time courses for the incorporation of labeled acetate into lipids in the liver and epididy-mal adipose tissue (adipose tissue) after the oral administration to rats were examined for 10d. The labeled acetate was abundantly incorporated into lipids, mainly into triacylglycer-ols (TAG) in the liver, reached a maximum at 2h after the administration and then quickly decreased. In the adipose tissue, the incorporation of the acetate reached a maximum after 8h and began to decrease slowly after 2d. The acetate incorporation into the lipids was markedly lower in the liver, plasma and adipose tissue of rats fed the corn oil diet than in those fed the fat-free diet. However, the half-lives of esterified fatty acids were similar in both dietary groups. The half-lives of esterified C16:0 and C18:1 in the decreasing phase were 5.4 and 8.9h, respectively, in the liver, and 4.3 and 5.6d, in the adipose tissue. The time courses for incorporation into plasma lipids were parallel to those in the liver. Thus the fatty acids synthesized in the liver appeared to be transported to adipose tissues and to stay there longer. Moreover, it is remarkable that 30% of the acetate radioactivities administered were found after 2h in the whole liver: 75% of the products from the acetate at the maximum were lipids and 61% of the lipids, TAG. The major products from acetate in the liver were lip-ids.
