期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2002
卷号：48
期号：3
页码：251-254
DOI：10.3177/jnsv.48.251
出版社：Center for Academic Publications Japan
摘要：An ingestion of tomato powder rich in lycopene was examined for its effect on mice with Parkinson's disease-like syndrome induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). To assess the preventive effect of tomato against the MPTP-in-duced selective destruction of dopaminergic nigrostrie, we determined striatal dopamine (DA). A4-wk ingestion of the experimental diet containing 20% (w/w) lyophilized tomato powders before MPTP treatment prevented a decrease in the DA level. This suggests that the tomato ingestion might serve as a preventive against neurodegenerative diseases such as Parkinson's disease caused by MPTP and other environmental toxins.
