期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1995
卷号：41
期号：1
页码：115-125
DOI：10.3177/jnsv.41.115
出版社：Center for Academic Publications Japan
摘要：The effect of glutamine (Gln)-supplemented diet on mi-togen response decreased immediately after a treadmill exercise was examined by measuring the proliferations of peripheral blood lympho-cytes (PBL) with phytohemagglutinin (PHA) and concanavalin A (ConA) in male Fisher rats. Although the plasma Gin concentration was significantly decreased in the control group immediately after a treadmill exercise (20 m/min, 60 min) compared to rested rats, plasma Gin concen-tration of rats fed Gln-supplemented diet for 3 weeks was significantly higher than that of control group in resting and was not significantly decreased even immediately after a treadmill exercise. In addition, proliferation of PBL with PHA or ConA and interleukin 2 (IL2) produc-tion were also significantly decreased immediately after a treadmill exer-cise in control group. On the contrary, their functions were almost maintained in Gin-supplemented group even immediately after a treadmill exercise. PBL from rats fed Gln-supplemented diet showed a higher response to mitogens such as PHA and ConA compared to the control group. Furthermore, their PBL showed higher incorporation of [3H]Gln compared to that of the control group irrespective of treadmill exercise. These results indicate that the preventive effect of Gln-supplemented diet on mitogen response decreased after a treadmill exercise is due to an increased response to mitogen and increased uptake of Gin as sources of fuel and nucleotides to the immune cells.
