期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1994
卷号：40
期号：5
页码：421-430
DOI：10.3177/jnsv.40.421
出版社：Center for Academic Publications Japan
摘要：Long-term administration of a β-carotene preparation de-rived from Dunaliella bardawil , a β-carotene-rich algae, was studied in healthy young male volunteers. The daily administration of 60mg of the β-carotene preparation (30mg of all-trans β-carotene and 30mg of 9- cis β-carotene) was performed and β-carotene concentrations were deter-mined in the plasma, red blood cells (RBC), platelets (PLT), and mononuclear cells (MN). The all-trans β-carotene level increased four-, two-, and threefold the baseline in plasma, PLT, and MN, respectively. Basal levels of 9- cis β-carotene in plasma, PLT, and MN were low and found as one-tenth, one-fifth, and one-fifth of all- trans β-carotene, which increased three-, two-, and 1.5-fold the baseline, respectively. Plasma and RBC α-tocopherol levels were not changed by the intake of β-carotene. No side effects or toxicities were documented in any of the subjects during the administration period. In conclusion, the bioavailability of β-carotene derived from Dunaliella bardawil was preferential for all- trans β-carotene, although a small amount of the 9- cis form was detected in the plasma and blood cells.
