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  • 标题:Response of Liver Microsomal Mixed-Function Oxidases to Dietary Linoleic Acid Levels in Rats
  • 本地全文:下载
  • 作者:Morio SAITO ; Michio YAMAGUCHI
  • 期刊名称:Journal of Nutritional Science and Vitaminology
  • 印刷版ISSN:0301-4800
  • 电子版ISSN:1881-7742
  • 出版年度:1993
  • 卷号:39
  • 期号:4
  • 页码:411-418
  • DOI:10.3177/jnsv.39.411
  • 出版社:Center for Academic Publications Japan
  • 摘要:Responses of the activities of liver microsomal mixed-function oxidases (MFOs) induced by phenobarbital (PB) to dietary linoleic acid (LA) levels were investigated in rats. Diets varied in LA content (0, 1.8, 4.1, 7.0, or 13.8 energy %) were fed to rats for 16 days. The activities of MFOs did not change significantly with increasing the dietary LA level, where they reached a plateau even at 1.8 energy%, although the fatty acid composition of liver microsomal lipids reflected well that of dietary lipids. Accordingly, 2 energy% of LA as essential fatty acid seemed to be sufficient to supply the dietary requirement as assessed by the activities of PB-induced MFOs.
  • 关键词:dietary lipid;linoleic acid level;dose-response;mixed-function oxidase;cytochrome P-450;phenobarbital;liver microsomes;microsomal fatty acid composition;rat
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